Leiomyosarcoma and Smooth Muscle Sarcomas

Alternative diagnostic terms
None

Common anatomical locations
Lower and upper extremities, retroperitoneum, abdomen/pelvis, and trunk.

Pathology comment
Fascicles of eosinophilic spindled cells with blunt-ended nuclei showing variable pleomorphism; immunolabeling for SMA, desmin, and/or caldesmon.

Source
Bridge JA, Dry SM, Fröhling S. Leiomyosarcoma. In: WHO Classification of Tumors Editorial Board. Soft tissue and bone tumors [Internet]. Lyon (France): International Agency for Research on Cancer; 2020 [2024 Dec 29]. (WHO Classification of Tumors Series, 5th ed.; vol. 3). Available from: https://tumourclassification.iarc.who.int/login?redirecturl=%2Fchapters%2F33

For diagnosis or treatment
Any center listed in the Sarcoma Centers Directory »

Patient advocacy
Any organization with an established program for patient triage, support, and education. See Patient Support Organizations »

Diagnostic-specific organizations:
National Leiomyosarcoma Foundation
Leiomyosarcoma
The Cynthia Soloman Holmes Foundation

Clinical trials
SARC Clinical Trials – None
Find other clinical studies registered on ClinicalTrials.gov

Alternative diagnostic terms
None

Common anatomical locations
Most common in the deep soft tissues of the lower extremity.

Pathology comment
Fascicular proliferation of variably atypical eosinophilic spindle cells, which show mitotic activity; dense inflammatory infiltrate, most often lymphoid or histiocytic/xanthomatous, but the composition is variable; immunopositivity for smooth muscle antigens.

Source
Bridge JA, Fletcher CDM, Mertens F. Inflammatory leiomyosarcoma. In: WHO Classification of Tumors Editorial Board. Soft tissue and bone tumors [Internet]. Lyon (France): International Agency for Research on Cancer; 2020 [2024 Dec 29]. (WHO Classification of Tumors Series, 5th ed.; vol. 3). Available from: https://tumorclassification.iarc.who.int/chapters/33.

For diagnosis or treatment
Any center listed in the Sarcoma Center Directory »

Patient advocacy
Any organization with an established program for patient triage, support, and education. See Patient Support Organizations »

Clinical trials
SARC Clinical Trials – None
Find other clinical studies registered on ClinicalTrials.gov

Alternative diagnostic terms
None

Common anatomical locations
Pending

Pathology comment
Pending

Source
Pending

For diagnosis or treatment
Any center listed in the Sarcoma Center Directory »

Patient advocacy
Any organization with an established program for patient triage, support, and education. See Patient Support Organizations »

Diagnostic-specific organizations:
National Leiomyosarcoma Foundation
The Cynthia Soloman Holmes Foundation

Clinical trials
SARC Clinical Trials – None
Find other clinical studies registered on ClinicalTrials.gov